company news about Ultrasonic coating method - the coating process of active drugs

Ultrasonic coating method - the coating process of active drugs

Abstract: The development of drug-eluting stents requires the establishment of a harmonious and mutually beneficial relationship between the stent, the drug carrier coating, the drug and the vascular wall. This requires a more sophisticated and specialized high-tech approach to the drug-eluting stents development process Sprayed in a variety of issues, this experiment mainly to solve the stent during the development of surface coating preparation.

Key words: active drug; ultrasonic medical spraying equipment;

The active drug, which is based on the inert coating is added bioactive substances, not only can improve the blood compatibility of the coating, but also in the early stent implantation (thrombosis peak), through the release of high concentrations of drugs, and positive Effective inhibition of platelet deposition, reducing intimal hyperplasia, and drug release process by the drug carrier material molecular weight and coating thickness.

The coating of active drug (or with drug carrier material) is the key to the success or failure of the whole coating process. Therefore, the development of drug coating process has been going on in full swing. Various coating processes have been continuously updated and improved. However, there are still some limitations of the current coating technology. There are physical and chemical methods for coating drugs on the surface of the stent. Among them, the physical coating method mainly uses immersion and spraying, while the chemical method mainly uses the electrochemical principle for electroplating . First, the soaking and spraying of the coating process, the uniformity of the coating surface is not easy to control the coating and the surface of the stent is relatively unsteady, often require repeated coating to control the coating surface properties and thickness The main disadvantage of the electrochemical coating method is that the scaffold material can only be composed of a conductor or a semiconductor. The process is complicated and the large-scale production is difficult. The applied active drug generally needs to be chemically modified.

The Company to overcome the limitations of existing coating technology research and development of ultrasonic medical spraying equipment, ultrasonic coating method using electronic high-frequency oscillation, causing high frequency resonance ceramic atomized ultrasound generated. Ultrasonic cavitation occurs when it propagates in water. Ultrasound medical devices use hole explosions that occur between water and air to smash the water around the holes into 10-90 micron particles, which are sprayed to form extremely fine coatings. The main advantages of ultrasonic medical spraying equipment developed by CHI-Fei Ultrasonic are as follows: the process is simple and easy to operate without complicated equipment; the drug release is easier to control; the large-scale production is easy; and the scaffold material can be applied to a metal-based Non-metallic materials produced stent; coating and stent surface adsorption close, not easy to fall off; Coating surface more uniform, the experimental environment has little effect on the coating; No need to repeat the coating; High degree of automation.

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